Datum: 2024-02-19 Verleger: 紫鸽电气 Durchsuche: 93
The objective of this research were to view the fresh new relationship off lean muscle mass (LBM) towards growth of vasomotor periods (VMS) as women changeover as a consequence of menopausal.
This study was a vacation access to analysis readily available for personal fool around with of follow-up check outs six by way of ten getting professionals for the the study off Ladies Fitness Across the nation. The study checked-out 2533 female, involving the many years 42–52 decades, on a yearly basis more than a10-seasons months. Research is modeled having contacts from lean muscle mass and you can VMS. Alterations in LBM as earlier see and because standard have been plus modeled as well as differences in mode using digital logistic regression, modifying to possess covariates.
LBM are somewhat related to concurrent VMS (p = .036), % change in LBM because the early in the day head to (p = .003), per cent alter once the baseline (p
Menopausal is a big enjoy in lot of ladies’ lifetime since it marks the end of the absolute reproductive lives. For some female, menopausal arise between your age forty and you may 58 years on the mediocre becoming 51 age . From the 80–96% of females feel lighter so you can really serious actual or psychological menopause-relevant complaints as they strategy menopause because of decreasing estrogen levels . Attacks are priced between very hot flashes and you can night sweats, depression, irritation, sleep problems, enhanced belly postimyynti morsian fat size, enhanced incidence away from metabolic syndrome, and you may increased chance of cardiovascular disease . Hot flashes and you can evening sweats will be the typical the signs of menopausal consequently they are with each other referred to as vasomotor episodes (VMS). It is stated that 60–80% of women have a tendency to sense VMS at some point inside the menopause transition .
As they change courtesy menopause, feminine tend to additionally experience a decrease in basal metabolic rate and you will a loss of lean muscle mass which advances the risk of putting on weight and you will carrying excess fat . Sarcopenia increases and is extremely common throughout menopausal which is mostly due to an instability between strength protein synthesis and you can malfunction, led to from the a rise in oxidative be concerned, pro-soreness markers, and hormonal changes . Research demonstrates that muscles energy and you can quality (ratio off muscle mass power to help you size) is adversely of the seriousness off menopause attacks owed so you’re able to declining degrees of sex hormone as well as the resulting increase in oxidative fret . Postmenopausal feminine have been shown to provides notably large oxidative worry bloodstream marker levels minimizing anti-oxidant capabilities according to premenopausal female .
For postmenopausal women, chronic systemic inflammation, oxidative stress, abdominal visceral adipose tissue, dyslipidemia, sarcopenia, and a sedentary lifestyle are all risk factors for metabolic syndrome . A systematic review found that the menopausal transition is associated with a decline in estrogen, growth hormone, insulin-like growth factor (IGF-1), and dehydroepiandrosterone (DHEA), a decrease in muscle protein synthesis, and an increase in catabolic factors such as the pro-inflammatory cytokines, and tumor necrosis factor alpha (TNF-?) or interleukine 6 (IL-6) . A recent study found that weight-adjusted lean body mass (LBM) and skeletal muscle area were protective against weight-associated insulin resistance and metabolic abnormalities suggesting that women with lower muscle mass and fewer estrogen receptors are therefore at greater risk for metabolic complications . Decreased LBM has been found to be the most important contributor to changes in metabolism for postmenopausal women as it correlates to low whole-body fat oxidation and energy expenditure which in turn are associated with high visceral fat mass and low insulin resistance . Maintaining adequate levels of muscle mass as women transition into menopause may play a role in minimizing the risks of sarcopenic obesity and protect against the development of deleterious metabolic conditions commonly associated with menopause. However, little is known regarding the role of LBM and its influence on menopausal symptoms throughout the transition period. The following hypotheses were examined: Hypothesis 1 (H1) – Lower concurrent LBM will be associated with greater concurrent incident reporting of VMS; Hypothesis 2 (H2) – In longitudinal analyses, lower LBM over time, since baseline, will be associated with greater incident reporting of VMS; Hypothesis 3 (H3) – In longitudinal analyses, lower LBM over time, since last annual visit, will be associated with greater incident reporting of VMS.
